HZ-52

• 产品号: H999750
• 分子式: C24H26ClN3O2S
• 分子量: 456.00014

产品别名

• 标题: HZ-52
• IUPAC标准名: 2-({4-chloro-6-[(4-phenylphenyl)amino]pyrimidin-2-yl}sulfanyl)octanoic acid
• IUPAC传统名: 2-({4-chloro-6-[(4-phenylphenyl)amino]pyrimidin-2-yl}sulfanyl)octanoic acid
• 别名: 2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]octanoic Acid; HZ 52

产品详细信息

详细说明 (English)

A potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. It also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects ag

参考文献

• Greiner, C. et al.: Br. J. Pharmacol., 164, 781 (2011)
• Koeberle, A. et al.: J. Med. Chem., 51, 8068 (2011)