42-O-[2-[[Hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]ethyl] Rapamycin Inner Salt >75%

• 产品号: H972100
• CAS号: 1062645-51-5
• 分子式: C58H95N2O17P
• 分子量: 1123.351861
• 保 存: -20°C Freezer

产品别名

• 标题: 42-O-[2-[[Hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]ethyl] Rapamycin Inner Salt >75%
• IUPAC标准名: 2-{[(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl]oxy}ethyl 2-(trimethylazaniumyl)ethyl phosphate
• IUPAC传统名: 2-{[(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl]oxy}ethyl 2-(trimethylammonio)ethyl phosphate
• 别名: ATG 181

产品登记号

• CAS号: 1062645-51-5

产品性质

• 外观: White to Off-White Solid
• 熔点: 135-140°C
• 溶解度: Methanol
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

A phosphocholine ester metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000).

参考文献

• Zollinger, M. et al.: Drug. Metab. Disp., 36, 1457 (2008)
• Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2008)