Hydroxy Terbinafine β-D-Glucuronide

• 产品号: H956175
• CAS号: 99473-12-8
• 分子式: C27H33NO7
• 分子量: 483.55342

产品别名

• 标题: Hydroxy Terbinafine β-D-Glucuronide
• IUPAC标准名: (2R,3R,4R,5S,6S)-6-{[(5E)-2,2-dimethyl-7-[methyl(naphthalen-1-ylmethyl)amino]hept-5-en-3-yn-1-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid
• IUPAC传统名: (2R,3R,4R,5S,6S)-6-{[(5E)-2,2-dimethyl-7-[methyl(naphthalen-1-ylmethyl)amino]hept-5-en-3-yn-1-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid
• 别名: (E)-2,2-Dimethyl-7-[methyl(1-naphthalenylmethyl)amino]-5-hepten-3-ynyl β-D-Glucopyranosiduronic Acid

产品登记号

• CAS号: 99473-12-8

产品性质

• 外观: Yellow Solid
• 熔点: 105-107°C
• 溶解度: Methanol

产品详细信息

详细说明 (English)

A metabolite of Terbinafine, an orally active, antimycotic allylamine related to naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis.

参考文献

• Gazinger, U., et al.: Proc. 13th Int. Congr. Chemother., 6, 116/52 (1983)
• Shadomy, S., et al.: Sabouraudia, 23, 125 (1983)
• Evans, E.G.V., et al.: Brit. Med. J., 318, 1031 (1999)