4-Hydroxy Estradiol 1-N3-Adenine

• 产品号: H942100
• CAS号: 428506-88-1
• 分子式: C23H27N5O3
• 分子量: 421.49218

产品别名

• 标题: 4-Hydroxy Estradiol 1-N3-Adenine
• IUPAC标准名: (1S,10R,11S,14S,15S)-3-(6-amino-3H-purin-3-yl)-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-triene-5,6,14-triol
• IUPAC传统名: (1S,10R,11S,14S,15S)-3-(6-aminopurin-3-yl)-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-triene-5,6,14-triol
• 别名: 4-OH-E2-1-N3Ade; (17β)-1-(6-Amino-3H-purin-3-yl)estra-1,3,5(10)-triene-3,4,17-triol

产品登记号

• CAS号: 428506-88-1

产品详细信息

详细说明 (English)

4-Hydroxy Estradiol 1-N3-Adenine is an estrogen metabolite formed with DNA which can lead to the mutations that initiate breast, prostate, and other types of cancer. The N3Ade depurinating adducts could serve as biomarkers to predict the risk of breast ca

参考文献

• Chakravarti, D., et al.: Mutat. Res., 456, 17 (2000)
• Liehr, J., et al.: Endocr. Rev., 21, 4054 (2000)
• Chakravarti, D., et al.: Oncogene, 20, 7945 (2000)
• Cavalieri, E., et al.: Chem. Res. Toxicol., 14, 1041 (2000)