4α-Hydroxy Cholesterol

• 产品号: H917975
• CAS号: 34310-86-6
• 分子式: C27H46O2
• 分子量: 402.65294
• 保 存: -20°C Freezer

产品别名

• 标题: 4α-Hydroxy Cholesterol
• IUPAC标准名: (1S,2R,5S,6S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-7-ene-5,6-diol
• IUPAC传统名: (1S,2R,5S,6S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-7-ene-5,6-diol
• 别名: (3β,4α)-Cholest-5-ene-3,4-diol; Cholest-5-ene-3β,4α-diol

产品登记号

• CAS号: 34310-86-6

产品性质

• 外观: Off-White to Brownish Orange Solid
• 熔点: >177°C (dec.)
• 溶解度: Chloroform
• 溶解度: Ethyl Acetate
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.

参考文献

• Breuer, O., et al.: J. Lipid Res., 36, 2275 (1995)
• Pikuleva, I., et al.: J. Biol. Chem., 273, 18153 (1995)
• Chawla, A., et al.: Science, 294, 1866 (1995)
• Bodin, K., et al.: J. Biol. Chem., 276, 38685 (1995)