11α-Hydroxy Canrenone

• 产品号: H883500
• CAS号: 192569-17-8
• 分子式: C22H28O4
• 分子量: 356.45532
• 保 存: -20°C Freezer

产品别名

• 标题: 11α-Hydroxy Canrenone
• IUPAC标准名: (2R,2'R,15'S,17'R)-17'-hydroxy-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecane]-6',8'-diene-5,5'-dione
• IUPAC传统名: (2R,2'R,15'S,17'R)-17'-hydroxy-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecane]-6',8'-diene-5,5'-dione
• 别名: (11α,17α)-11,17-Dihydroxy-3-oxopregna-4,6-diene-21-carboxylic Acid γ-Lactone

产品登记号

• CAS号: 192569-17-8

产品性质

• 外观: Yellow Solid
• 熔点: 232-234°C
• 溶解度: Acetone
• 溶解度: Chloroform
• 溶解度: Methanol
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

11α-Hydroxy Canrenone is the key intermediate in the synthesis of Eplerenone, a cardiovascular drug. Canrenone was biotransformed into 11α-Hydroxycanrenone by Aspergillus ochraceus SIT34205.

参考文献

• Luetscher, J., et al.: J. Clin. Invest., 29, 1576 (1950)
• Gaunt, R., et al.: J. Clin. Endocrinol. Metab., 15, 621 (1950)
• McMahon, E., et al.: Curr. Opin. Pharm., 1, 190 (1950)
• McMahon, E., et al.: Curr. Pharm. Des., 9, 1065 (1950)