4-Hydroxy Atorvastatin Calcium Salt

• 产品号: H828961
• 分子式: C33H33CaFN2O6
• 分子量: 612.7013232
• 保 存: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: 4-Hydroxy Atorvastatin Calcium Salt
• IUPAC标准名: calcium (3R,5R)-7-[2-(4-fluorophenyl)-4-[(4-oxidophenyl)carbamoyl]-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
• IUPAC传统名: calcium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-4-[(4-oxidophenyl)carbamoyl]-3-phenylpyrrol-1-yl]-3,5-dihydroxyheptanoate
• 别名: (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-4-[[(4-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic Acid Calcium Salt; p-Hydroxyatorvastatin Calcium Salt

产品性质

• 外观: Light Beige Solid
• 熔点: 181-186°C
• 溶解度: Methanol
• 保存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

4-Hydroxyatorvastatin is a hydroxylated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in pati

参考文献

• Smith, S. et al.: Am. J. Cardiol., 80, 10H (1997)
• Jacobsen, W. et al.: Drug Metab. Dispos., 28, 1369 (1997)
• Istvan, E. et al.: Science, 292, 1160 (1997)
• Tabernero, L. et al.: J. Biol. Chem., 278, 19933 (1997)
• Bratton, L. et al.: Bioorg. Med. Chem., 15