2-Hydroxy Atorvastatin-d5 Disodium Salt

• 产品号: H828952
• CAS号: 1276537-19-9
• 分子式: C33H33FN2Na2O6
• 分子量: 618.6028632
• 保 存: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: 2-Hydroxy Atorvastatin-d5 Disodium Salt
• IUPAC标准名: disodium (3R,5R)-7-[2-(4-fluorophenyl)-4-[(2-oxidophenyl)carbamoyl]-3-(^2H₅)phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
• IUPAC传统名: disodium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-4-[(2-oxidophenyl)carbamoyl]-3-(^2H₅)phenylpyrrol-1-yl]-3,5-dihydroxyheptanoate
• 别名: o-Hydroxyatorvastatin Disodium Salt; PD 152873; (βR,δR)-2-(4-fluorophenyl)-β,δ-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-(phenyl-d5)-1H-pyrrole-1-heptanoic Acid Disodium Salt; BMS 243887-01

产品登记号

• CAS号: 1276537-19-9

产品性质

• 外观: Yellow Solid
• 熔点: 132-134°C
• 溶解度: Methanol
• 保存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

A deuterated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterole

参考文献

• Smith, S., et al.: Am. J. Cardiol., 80, 10H (1997)
• Jacobsen, W., et al.: Drug Metab. Dispos., 28, 1369 (1997)
• Istvan, E., et al.: Science, 292, 1160 (1997)
• Tabernero, L., et al.: J. Biol. Chem., 278, 19933 (1997)
• Bratton, L., et al.: Bioorg. Med. Chem