GW 501516

• 产品号: G931500
• CAS号: 317318-70-0
• 分子式: C21H18F3NO3S2
• 分子量: 453.4977296
• 保 存: Refrigerator

产品别名

• 标题: GW 501516
• IUPAC标准名: 2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
• IUPAC传统名: 2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxyacetic acid
• 别名: GW 1516; Methyl-methyl-trifluoromethylphenyl-thiazolyl-methylsulfanyl-phenoxy-acetic Acid; 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid

产品登记号

• CAS号: 317318-70-0

产品性质

• 外观: Off-White to Pale Yellow Solid
• 熔点: 134-136°C
• 溶解度: DMSO
• 溶解度: Methanol
• 保存条件: Refrigerator

产品详细信息

详细说明 (English)

An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα

参考文献

• Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001)
• Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2001)
• Wang, Y.X., et al.: Cell, 113, 159 (2001)