GSK PERK Inhibitor

• 产品号: G797800
• CAS号: 1337531-89-1
• 分子式: C24H19F4N5O
• 分子量: 469.4341728
• 保 存: Refrigerator

产品别名

• 标题: GSK PERK Inhibitor
• IUPAC标准名: 1-(5-{4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2,3-dihydro-1H-indol-1-yl)-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethan-1-one
• IUPAC传统名: 1-(5-{4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl}-2,3-dihydroindol-1-yl)-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone
• 别名: 3-Fluoro-GSK2606414; 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone

产品登记号

• CAS号: 1337531-89-1

产品性质

• 外观: Pale Yellow Solid
• 熔点: 237-240°C (dec.)
• 溶解度: DMSO
• 保存条件: Refrigerator

产品详细信息

详细说明 (English)

GSK PERK Inhibitor is an inhibitors of PERK, an important transmembrane protein of endoplasmic reticulum (ER). GSK PERK Inhibitor can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response p

参考文献

• Baltzis, D. et al.: J. Biol. Chem., 282, 31675 (2007)
• Axten, J. M.et al,: J. Med. Chem. 55(16) 7193 (2012).