4-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine Hydrochloride

• 产品号: F595220
• CAS号: 1012886-75-7
• 分子式: C12H15ClFN
• 分子量: 227.7056032
• 保 存: -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: 4-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine Hydrochloride
• IUPAC标准名: 4-(4-fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine hydrochloride
• IUPAC传统名: 4-(4-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine hydrochloride
• 别名: 4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-methylpyridine Hydrochloride; 1-Methyl-4-(4'-fluorophenyl)-1,2,3,6-tetrahydropyridine Hydrochloride

产品登记号

• CAS号: 1012886-75-7

产品性质

• 外观: Off-White Solid
• 熔点: 171-174°C
• 溶解度: Methanol
• 溶解度: Water
• 保存条件: -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

The active metabolite of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (M325910), N-Methyl-4-phenylpyridinium (MPP+), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease.

参考文献

• Gerlach, M., et al.: Eur. J. Pharmacol., 208, 273 (1991)
• Tipton, K., et al.: J. Neurochem., 61, 1191 (1991)
• Wimalasena, D., et al.: J. Biol. Chem., 279, 15298 (1991)