N-(9-Fluorenylmethoxycarbonyl)-4',6,8,11-tetra-O-benzoyl Doxorubicin

• 产品号: F472435
• 分子式: C70H55NO17
• 分子量: 1182.1822

产品别名

• 标题: N-(9-Fluorenylmethoxycarbonyl)-4',6,8,11-tetra-O-benzoyl Doxorubicin
• IUPAC标准名: (1S,3S)-12-(benzoyloxy)-1-{[(2R,4R,5R,6R)-5-(benzoyloxy)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-6-methyloxan-2-yl]oxy}-3-[2-(benzoyloxy)acetyl]-3-hydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-5-yl benzoate
• IUPAC传统名: (1S,3S)-12-(benzoyloxy)-1-{[(2R,4R,5R,6R)-5-(benzoyloxy)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-6-methyloxan-2-yl]oxy}-3-[2-(benzoyloxy)acetyl]-3-hydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-5-yl benzoate
• 别名: (8S,10S)-7,8,9,10-tetrahydro-8-hydroxy-6,11-dibenzoyloxy-8-(2-benzoyloxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-benzyloxy-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione

产品性质

• 外观: Yellow Solid
• 溶解度: Dichloromethane

产品详细信息

详细说明 (English)

N-(9-Fluorenylmethoxycarbonyl) Doxorubicin (F472430) derivative. Used in the preparation of a modified Doxorubicin (ANG1007) and Etoposide (ANG1009) useful due to their brain penetration ability.

参考文献

• Che, C. et al.: J. Med. Chem. 53, 2814 (2010)