FK-506 (Tacrolimus)

• 产品号: F370000
• CAS号: 104987-11-3
• 分子式: C44H69NO12
• 分子量: 804.01816
• 保 存: -20°C Freezer

产品别名

• 标题: FK-506 (Tacrolimus)
• IUPAC标准名: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25R,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3S,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• IUPAC传统名: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25R,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3S,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• 别名: Protopic; Fujimycin; Tsukubaenolide; Tacrolimus; FR 900506; Advagraf; L 679934; Prograf; TacroBell

产品登记号

• CAS号: 104987-11-3

产品性质

• 外观: White to Off-White Solid
• 熔点: 125-129°C
• 溶解度: Acetone
• 溶解度: Chloroform
• 溶解度: DMSO
• 溶解度: Ether
• 溶解度: Ethanol
• 溶解度: Ethyl Acetate
• 溶解度: Methanol
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 rel

参考文献

• Asano, K., et al.: In Vivo, 10, 537 (1996)
• McCall, E., et al.: Circ. Res., 79, 1110 (1996)
• Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996)
• Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996)
• Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318,