Everolimus

• 产品号: E945400
• CAS号: 159351-69-6
• 分子式: C53H83NO14
• 分子量: 958.22442
• 保 存: Hygroscopic, Store under Inert atmosphere -20°C Freezer

产品别名

• 标题: Everolimus
• IUPAC标准名: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• IUPAC传统名: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• 别名: 42-O-(2-Hydroxy)ethyl Rapamycin; RAD 001; SDZ-RAD; XIENCE V; 40-O-(2-Hydroxyethyl)rapamycin; Afinitor; Certican; RAD

产品登记号

• CAS号: 159351-69-6

产品性质

• 外观: Off White Solid
• 熔点: 110-115°C
• 溶解度: Chloroform
• 保存条件: Hygroscopic, Store under Inert atmosphere -20°C Freezer

产品详细信息

详细说明 (English)

Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.

参考文献

• Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001)
• Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001)
• Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2001)