Erismodegib

• 产品号: E615200
• CAS号: 956697-53-3
• 分子式: C26H26F3N3O3
• 分子量: 485.4981496

产品别名

• 标题: Erismodegib
• IUPAC标准名: N-{6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
• IUPAC传统名: N-{6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
• 别名: NVP-LDE 225; LDE 225; rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-1,1'-biphenyl]-3-carboxamide

产品登记号

• CAS号: 956697-53-3

产品详细信息

详细说明 (English)

A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic.

参考文献

• Berman, D., et al.: Science, 297, 1559 (2002)
• Varjosalo, M., et al.: Cell, 133, 537 (2002)
• Theunissen, J., et al.: Cancer Res., 69, 6007 (2002)