Epothilone D (synthetic)

• 产品号: E589000
• CAS号: 189453-10-9
• 分子式: C27H41NO5S
• 分子量: 491.68314
• 保 存: -20°C Freezer

产品别名

• 标题: Epothilone D (synthetic)
• IUPAC标准名: (4S,7R,8S,9S,13Z)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
• IUPAC传统名: (4S,7R,8S,9S,13Z)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
• 别名: Epothilone D; Epo D; Desoxyepothilone B; (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione; 12,13-Desoxyepothilone B; (-)-Desoxyepothilone B; (-)-Epothilone D; 12,13-Deoxyepothilone B; KOS 862; NSC 703147

产品登记号

• CAS号: 189453-10-9

产品性质

• 外观: White Solid
• 熔点: 63-66°C
• 溶解度: Chloroform
• 溶解度: DMSO
• 溶解度: Ether
• 溶解度: Ethyl Acetate
• 溶解度: Methanol
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumou

参考文献

• Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995)
• Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (1995)
• Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)