Epothilone B (synthetic)

• 产品号: E588990
• CAS号: 152044-54-7
• 分子式: C27H41NO6S
• 分子量: 507.68254
• 保 存: -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: Epothilone B (synthetic)
• IUPAC标准名: (1S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
• IUPAC传统名: (1S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
• 别名: (-)-Epothilone B; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; EPO 906A; Epothilone B; EPO 906; Patupilone

产品登记号

• CAS号: 152044-54-7

产品性质

• 外观: White Powder
• 熔点: 95-97°C
• 溶解度: Chloroform
• 溶解度: Dichloromethane
• 溶解度: DMSO
• 溶解度: Ethanol
• 溶解度: Methanol
• 保存条件: -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the c

参考文献

• Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995)
• Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (1995)
• Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)