Epothilone A

• 产品号: E588980
• CAS号: 152044-53-6
• 分子式: C26H39NO6S
• 分子量: 493.65596

产品别名

• 标题: Epothilone A
• IUPAC标准名: (1S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
• IUPAC传统名: (-)-epothilone A
• 别名: Epothilone A; (-)-Epothilone A; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

产品登记号

• CAS号: 152044-53-6

产品详细信息

详细说明 (English)

The epothilones are a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A, B isolated from Sorangium cellulosum was associated with cell cycle arrest at G2/M transition and apoptosis that was resisted with overexpression of

参考文献

• Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995)
• Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (1995)
• Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)