2,4-Dibenzyl-5-oxothiadiazolidine-3-thione

• 产品号: D417960
• CAS号: 72966-20-2
• 分子式: C16H14N2OS2
• 分子量: 314.42516
• 保 存: -20°C Freezer

产品别名

• 标题: 2,4-Dibenzyl-5-oxothiadiazolidine-3-thione
• IUPAC标准名: 2,4-dibenzyl-3-sulfanylidene-1,2,4-thiadiazolidin-5-one
• IUPAC传统名: 2,4-dibenzyl-3-sulfanylidene-1,2,4-thiadiazolidin-5-one
• 别名: 2,4-Bis(phenylmethyl)-3-thioxo-1,2,4-thiadiazolidin-5-one; GSK-3β Inhibitor III

产品登记号

• CAS号: 72966-20-2

产品性质

• 外观: White to Off-White Solid
• 熔点: 104-107°C
• 溶解度: Chloroform
• 溶解度: Dichloromethane
• 溶解度: Ethyl Acetate
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

Glycogen Synthase Kinase-3β is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. An oxothiadiazolidine-3-thione analogue that acts as a non-ATP competitive inhibitor of GSK-3β ( IC50 =10uM).

参考文献

• Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)