N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-β]pyridine

• 产品号: D239630
• CAS号: 142784-25-6
• 分子式: C23H23N9O4
• 分子量: 489.48662
• 保 存: -20°C Freezer

产品别名

• 标题: N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-β]pyridine
• IUPAC标准名: 2-amino-9-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-({1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl}amino)-6,9-dihydro-1H-purin-6-one
• IUPAC传统名: 2-amino-9-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-({1-methyl-6-phenylimidazo[4,5-b]pyridin-2-yl}amino)-1H-purin-6-one
• 别名: dG-C8-PhIP; 2'-Deoxy-8-[(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]guanosine

产品登记号

• CAS号: 142784-25-6

产品性质

• 外观: Brownish Yellow Solid
• 熔点: >270°C (dec.)
• 溶解度: DMF
• 溶解度: DMSO
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

The DNA adduct formed from N-Hydroxy-PHIP. Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4).

参考文献

• Frandsen, H., et al.: Carcinogenesis, 13, 4, 629 (1992)
• Lin, D., et al.: Chem. Res. Toxicol., 5, 691 (1992)
• Mizukami, S., et al.: Biochemistry, 45, 2772 (1992)