Demecolceine

• 产品号: D230750
• CAS号: 518-11-6
• 分子式: C20H23NO5
• 分子量: 357.40032
• 保 存: -20°C Freezer

产品别名

• 标题: Demecolceine
• IUPAC标准名: (10S)-14-hydroxy-3,4,5-trimethoxy-10-(methylamino)tricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-13-one
• IUPAC传统名: (10S)-14-hydroxy-3,4,5-trimethoxy-10-(methylamino)tricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-13-one
• 别名: (7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one; NSC 36559; N-Desacetyl-N-methylcolchiceine; 7-Deacetamido-7-(methylamino)colchiceine

产品登记号

• CAS号: 518-11-6

产品性质

• 外观: Yellow Solid
• 熔点: 120-122°C
• 溶解度: Dichlormethane
• 溶解度: DMSO
• 溶解度: Methanol
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pa

参考文献

• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev