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Phenindione

产品号 DB00498 公司名称 DrugBank
CAS号 83-12-5 公司网站 http://www.ualberta.ca/
分子式 C15H10O2 电 话 (780) 492-3111
分子量 222.2387 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 381

产品价格信息

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产品别名

标题
Phenindione
IUPAC标准名
2-phenyl-2,3-dihydro-1H-indene-1,3-dione
IUPAC传统名
phenindione
商标名
Phenylin
Phenylindione
Phenylindanedione
Thrombasal
Hemolidione
Indema
Athrombon
Bindan
Cronodione
Diophindane
Eridione
Fenilin
PID
Phenhydren
Phenillin
Phenyline
Pindione
Danedion
Danilon
Danilone
Diadilan
Dindevan
Dineval
Emandion
Emandione
Fenhydren
Fenindion
Hedulin
Indion
Indon
Phenylen
Phenyllin
Rectadione
Theradione
Tromazal
Trombol

产品登记号

PubChem CID 4760
CAS号 83-12-5
PubChem SID 46505018

产品性质

疏水性(logP) 2.6
溶解度 27 mg/L (at 20 oC)

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Indication For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Pharmacology Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Toxicity Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Absorption Absorbed slowly from the gastrointestinal tract.
Half Life 5-10 hours
Protein Binding 88%
References
/ [Link]
External Links
Wikipedia

参考文献