(R)-N-Deacetyl Colchicine

• 产品号: D198921
• CAS号: 102419-91-0
• 分子式: C20H23NO5
• 分子量: 357.40032

产品别名

• 标题: (R)-N-Deacetyl Colchicine
• IUPAC标准名: (10R)-10-amino-3,4,5,14-tetramethoxytricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-13-one
• IUPAC传统名: (10R)-10-amino-3,4,5,14-tetramethoxytricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-13-one
• 别名: (+)-7-Deacetylcolchicine; (7R)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one

产品登记号

• CAS号: 102419-91-0

产品详细信息

详细说明 (English)

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pa

参考文献

• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev