Demecolcine-d3

• 产品号: D230787
• 分子式: C21H25NO5
• 分子量: 371.4269

产品别名

• 标题: Demecolcine-d3
• IUPAC标准名: (10S)-3,4,5,14-tetramethoxy-10-[(^2H₃)methylamino]tricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-13-one
• IUPAC传统名: (10S)-3,4,5,14-tetramethoxy-10-[(^2H₃)methylamino]tricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-13-one
• 别名: Colchamin-d3; Omain-d3; Deacetylmethylcolchicine-d3; Colcemid-d3; (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one-d3; NSC 3096-d3; Omaine-d3; Reichstein's F-d3; N-Desacetyl-N-methylcolchicine-d3

产品性质

• 外观: Faintly Yellow Crystalline Powder
• 熔点: 73-75°C
• 溶解度: Dichlormethane
• 溶解度: DMSO
• 溶解度: Methanol

产品详细信息

详细说明 (English)

An isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the

参考文献

• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev