Dabigatran Acyl-β-D-Glucuronide

• 产品号: D100085
• CAS号: 1015167-40-4
• 分子式: C31H33N7O9
• 分子量: 647.63522

产品别名

• 标题: Dabigatran Acyl-β-D-Glucuronide
• IUPAC标准名: (2S,3S,4S,5R,6S)-6-({3-[1-(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-1,3-benzodiazol-5-yl)-N-(pyridin-2-yl)formamido]propanoyl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
• IUPAC传统名: (2S,3S,4S,5R,6S)-6-({3-[1-(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1,3-benzodiazol-5-yl)-N-(pyridin-2-yl)formamido]propanoyl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
• 别名: N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine β-D-Glucopyranuronosyl Ester

产品登记号

• CAS号: 1015167-40-4

产品详细信息

详细说明 (English)

The major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys. NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (β anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (α and β anomers).

参考文献

• Becker, B., et al.: Biochem. J., 314, 249 (1996)
• Bailey, M., et al.: Chem. Biol. Interact., 145, 117 (1996)
• Blech, S., et al.: Drug Metab. Dispos., 2008, 36, 386 (1996)