Crizotinib-d4

• 产品号: C785002
• 分子式: C16H18N2O3
• 分子量: 286.32572

产品别名

• 标题: Crizotinib-d4
• IUPAC标准名: (3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-1-benzopyran-6-carbonitrile
• IUPAC传统名: cromakalim
• 别名: [3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl-d4)-1H-pyrazol-4-yl]pyridin-2-yl]amine; PF 02341066-d4; 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl-d4)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl-d4)-1H-pyrazol-4-yl]pyridin-2-ylamine; PF 2341066-d4

产品详细信息

详细说明 (English)

Labelled Crizotinib(C78500). A potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

参考文献

• Zou, H.Y. et al.: Cancer Res., 67, 4408 (2007)
• Cui, J.J. et al.: J. Med. Chem., No pp given (2007)
• Sasaki, T. et al.: Cancer. Res. et al.: 70, 10038 (2007)