6'-Cyano-2',3'-dihydro-5'-oxo-spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-7'-acetic Acid Ethyl Ester

• 产品号: C979190
• 分子式: C15H16N2O5
• 分子量: 304.29794

产品别名

• 标题: 6'-Cyano-2',3'-dihydro-5'-oxo-spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-7'-acetic Acid Ethyl Ester
• IUPAC标准名: ethyl 2-{6'-cyano-5'-oxo-3',5'-dihydro-2'H-spiro[1,3-dioxolane-2,1'-indolizine]-7'-yl}acetate
• IUPAC传统名: ethyl 2-{6'-cyano-5'-oxo-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indolizine]-7'-yl}acetate
• 别名: 6'-Cyano-2',3'-dihydro-5'-oxo-spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-7'-acetic Acid Ethyl Ester; NSC 633170

产品性质

• 外观: Green Solid
• 溶解度: Dichloromethane
• 溶解度: Methanol

产品详细信息

详细说明 (English)

Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents.

参考文献

• Wani, M.C., et al.: J. Med. Chem., 29, 2358 (1986)
• Miller, K.D., et al.: Invest. New Drugs, 22, 69 (1986)
• Punt, C.J.A., et al.: Eur. J. Cancer, 40, 1332 (1986)
• Wang, J.-Q., et al.: Bioorg. Med. Chem., 13, 549 (2005)