CP-154526 Hydrochloride

• 产品号: C781295
• CAS号: 257639-98-8
• 分子式: C23H33ClN4
• 分子量: 400.98792
• 保 存: Refrigerator

产品别名

• 标题: CP-154526 Hydrochloride
• IUPAC标准名: N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
• IUPAC传统名: N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
• 别名: CP 154526 Hydrochloride; N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Hydrochloride

产品登记号

• CAS号: 257639-98-8

产品性质

• 溶解度: Methanol
• 外观: Pale Yellow Solid
• 熔点: 167-169°C
• 溶解度: DMSO
• 保存条件: Refrigerator

产品详细信息

详细说明 (English)

A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maz

参考文献

• Lundkist, J. et al.: Eur. J. Pharmacol., 309, 195 (1996)
• Arbolius, L. et al.: J. pharmacol. Exp. Therap., 294, 588 (1996)
• Kehne, J.H. et al.: Neuropharmacol., 39, 1357 (1996)