CP-100356 Hydrochloride

• 产品号: C781250
• CAS号: 142715-48-8
• 分子式: C31H37ClN4O6
• 分子量: 597.10168
• 保 存: Refrigerator

产品别名

• 标题: CP-100356 Hydrochloride
• IUPAC标准名: 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine hydrochloride
• IUPAC传统名: 4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine hydrochloride
• 别名: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine monohydrochloride

产品登记号

• CAS号: 142715-48-8

产品性质

• 外观: Off-White to Light Tan Solid
• 熔点: 210-212°C
• 溶解度: Chloroform
• 溶解度: Methanol
• 保存条件: Refrigerator

产品详细信息

详细说明 (English)

CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356

参考文献

• Ayrton, A., et al.: Xenobiotica, 31, 469 (2001)
• Mizuno, N., et al.: Pharmacol. Rev., 55, 425 (2001)
• Fojo, T., et al.: Clin. Breast Cancer, 7, 749 (2001)
• Polli, J., et al.: Drug Metab. Dispos., 36, 695 92008),