CI-988

• 产品号: C432695
• CAS号: 130332-27-3
• 分子式: C35H42N4O6
• 分子量: 614.73118

产品别名

• 标题: CI-988
• IUPAC标准名: 3-{[(1R)-2-[(2R)-2-{[(adamantan-2-yloxy)carbonyl]amino}-3-(1H-indol-3-yl)-2-methylpropanamido]-1-phenylethyl]carbamoyl}propanoic acid
• IUPAC传统名: 3-{[(1R)-2-[(2R)-2-{[(adamantan-2-yloxy)carbonyl]amino}-3-(1H-indol-3-yl)-2-methylpropanamido]-1-phenylethyl]carbamoyl}propanoic acid
• 别名: 4-[[(1R)-2-[[(2R)-3-(1H-Indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic Acid; [R-(R*,R*)]-4-[[2-[[3-(1H-Indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic Acid; CI 988

产品登记号

• CAS号: 130332-27-3

产品详细信息

详细说明 (English)

CI-988 is a potent and selective cholecystokinin 2 (CCK-2) receptor antagonist that displays ~ 1600-fold selectivity over CCK1 receptors and has negligible affinity at other binding sites. CI-988 exhibits anxiolytic activity following oral administration.

参考文献

• Drysdale, M. et al.: Bioorg. Med. Chem. Lett., 2, 45 (1992)
• Moody, T.W. et al.: J. Pharmacol. Exp. Ther., 299, 1154 (1992)