Clasto-lactacystin(Omuralide)

• 产品号: C562500
• CAS号: 154226-60-5
• 分子式: C10H15NO4
• 分子量: 213.2304
• 保 存: -20°C Freezer

产品别名

• 标题: Clasto-lactacystin(Omuralide)
• IUPAC标准名: (1R,4R,5S)-1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
• IUPAC传统名: (1R,4R,5S)-1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
• 别名: Clasto-lactacystin β-Lactone; (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; Omuralide

产品登记号

• CAS号: 154226-60-5

产品性质

• 外观: White Solid
• 熔点: 186-187°C
• 溶解度: DMF
• 溶解度: Ethanol
• 溶解度: Hot Ethyl Acetate
• 溶解度: Methanol
• 溶解度: Pyridine
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induce

参考文献

• Craiu, A., et al.: J. Biol. Chem., 272, 13437 (1997)
• Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997)
• Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1997)
• Corey, E.J., et al.: J.A.C.S., 120, 2330 (1998)