4-Chloro Kynurenine

• 产品号: C366940
• CAS号: 75802-84-5
• 分子式: C10H11ClN2O3
• 分子量: 242.65894

产品别名

• 标题: 4-Chloro Kynurenine
• IUPAC标准名: 2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid
• IUPAC传统名: 2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid
• 别名: (+/-)-AV-101; α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid; (+/-)-α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid; 4-Cl-KYN

产品登记号

• CAS号: 75802-84-5

产品详细信息

详细说明 (English)

7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.

参考文献

• Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994)
• Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (1994)
• Palmer, G., et al.: Curr. Drug Targets, 2, 241 (1994)
• Wu, H., et al.: Exp. Neurol., 177, 222 (1994)