CHIR-98014

• 产品号: C292100
• CAS号: 556813-39-9
• 分子式: C20H17Cl2N9O2
• 分子量: 486.31408
• 保 存: Refrigerator

产品别名

• 标题: CHIR-98014
• IUPAC标准名: 2-N-(2-{[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]amino}ethyl)-5-nitropyridine-2,6-diamine
• IUPAC传统名: 2-N-(2-{[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]amino}ethyl)-5-nitropyridine-2,6-diamine
• 别名: N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine

产品登记号

• CAS号: 556813-39-9

产品性质

• 外观: Yellow Solid
• 熔点: 192-196°C
• 溶解度: DMSO
• 溶解度: Methanol
• 保存条件: Refrigerator

产品详细信息

详细说明 (English)

A glycogen synthase kinase-3 (GSK-3) inhibitor. Effects of GSK inhibitors on p-tau, GSK-3β activities and cell death were measured in a human neuronal cell line (LUHMES). Lithium and CHIR98014 reduced tau phosphorylation (Ser396) in the cortex and hippoca

参考文献

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• Guo