Celastrol

• 产品号: C249500
• CAS号: 34157-83-0
• 分子式: C29H38O4
• 分子量: 450.60962

产品别名

• 标题: Celastrol
• IUPAC标准名: (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
• IUPAC传统名: triterpene
• 别名: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic Acid; 3-Hydroxy-2-oxo-24-nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic Acid; Tripterin

产品登记号

• CAS号: 34157-83-0

产品性质

• 外观: Orange Red Solid
• 熔点: 219-230°C
• 溶解度: DMSO
• 溶解度: Methanol

产品详细信息

详细说明 (English)

An antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibito

参考文献

• Senger, D., et al.: Science, 219, 983 (1983)
• Folkman, J., et al.: Nature, 1, 27 (1983)
• He, W., et al.: Bioorg. Med. Chem. Lett., 8, 3659 (1983)
• Grosios, K., et al.: Inflamm. Res., 53, 133 (1983)
• Yang, H., et al.: Cancer Res., 66, 4758 (1983)