Canadine

• 产品号: C175175
• CAS号: 522-97-4
• 分子式: C20H21NO4
• 分子量: 339.38504

产品别名

• 标题: Canadine
• IUPAC标准名: 16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0^2,^1^0.0^4,^8.0^1^5,^2^0]henicosa-2(10),3,8,15,17,19-hexaene
• IUPAC传统名: 16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0^2,^1^0.0^4,^8.0^1^5,^2^0]henicosa-2(10),3,8,15,17,19-hexaene
• 别名: (±)-Tetrahydroberberine; Tetrahydroberberine; 5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine; 9-Deoxy-16,17-dihydroberberine; 9,10-Dimethoxy-2,3-(methylenedioxy)berbine; (±)-Canadine; Tetrahydroberberine,; NSC 36351; NSC 94918; Tetrahydroumbellatine; Xanthopuccine; dl-Canadine; dl-Tetrahydroberberine

产品登记号

• CAS号: 522-97-4

产品详细信息

详细说明 (English)

Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.

参考文献

• Duchowicz, P., et al.: Bioorg. Med. Chem., 14, 5876 (2006)
• Sun., et al.: Br. J. Pharmcol., 158, 1302 (2006)
• Deeb, O., et al.: Chem. Biol. Drug Des., 76, 255 (2006)