Cabozantinib L-Malate Salt

• 产品号: C051500
• CAS号: 1140909-48-3
• 分子式: C32H30FN3O10
• 分子量: 635.5931032
• 保 存: Refrigerator

产品别名

• 标题: Cabozantinib L-Malate Salt
• IUPAC标准名: (2S)-2-hydroxybutanedioic acid; 1-N'-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• IUPAC传统名: (-)-malic acid; cabozantinib
• 别名: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (2S)-2-Hydroxybutanedioic Acid; XL 184; Cabozantinib S-Malate

产品登记号

• CAS号: 1140909-48-3

产品性质

• 外观: Off-White Solid
• 熔点: 166-169°C
• 溶解度: DMSO
• 保存条件: Refrigerator

产品详细信息

详细说明 (English)

Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib sho

参考文献

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• Morello, S., et al.: J. Cell Physiol., 189, 285 (1999)
• Zhang, Y., et al.: Oncogene, 21, 217 (1999)