BIX 01294 Trihydrochloride

• 产品号: B591600
• 分子式: C28H38N6O2
• 分子量: 490.64032

产品别名

• 标题: BIX 01294 Trihydrochloride
• IUPAC标准名: N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
• IUPAC传统名: N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
• 别名: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine Trihydrochloride

产品详细信息

详细说明 (English)

G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor that H3K9me2 chromatin levels modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.

参考文献

• Kubicek, S. et al.: Mol. Cell., 25, 473 (2007)
• Huangfu, D et al.: Nat. Biotechnol., 26, 795 (2007)
• Chang, Y. et al.: Bat. Struct. Mol. Biol., 16, 312 (2007)