Bisindolylmaleimide XI Hydrochloride

• 产品号: B448530
• 分子式: C28H29ClN4O2
• 分子量: 489.00846

产品别名

• 标题: Bisindolylmaleimide XI Hydrochloride
• IUPAC标准名: 3-{8-[(dimethylamino)methyl]-6H,7H,8H,9H-pyrido[1,2-a]indol-10-yl}-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione hydrochloride
• IUPAC传统名: 3-{8-[(dimethylamino)methyl]-6H,7H,8H,9H-pyrido[1,2-a]indol-10-yl}-4-(1-methylindol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
• 别名: Ro 31-0432; 3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride

产品详细信息

详细说明 (English)

Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and

参考文献

• Wilkinson, S.E. et al.: Biochem. J., 294, 335 (1993)
• Liu, Q., Chen, X. et al.: . Circ. Res. 105, 194 (1993)
• Birchall, A.M. et al.: J. Pharmacol. Exp. Ther., 268, 922 (1993)