(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione

• 产品号: B415780
• CAS号: 189453-35-8
• 分子式: C39H69NO5SSi2
• 分子量: 720.20486

产品别名

• 标题: (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione
• IUPAC标准名: (4S,7R,9S,13Z,16S)-4,8-bis[(tert-butyldimethylsilyl)oxy]-5,5,7,9,13-pentamethyl-16-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
• IUPAC传统名: (4S,7R,9S,13Z,16S)-4,8-bis[(tert-butyldimethylsilyl)oxy]-5,5,7,9,13-pentamethyl-16-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
• 别名: [4S-[4R*,7S*,8R*,9R*,13Z,16R*(E)]]-4,8-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,5,7,9,13-pentamethyl-16-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione

产品登记号

• CAS号: 189453-35-8

产品性质

• 外观: White Foam
• 溶解度: Chloroform
• 溶解度: Dichloromethane
• 溶解度: Ethanol
• 溶解度: Ethyl Acetate
• 溶解度: Methanol
• 溶解度: Toluene

产品详细信息

详细说明 (English)

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical

参考文献

• Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999)
• Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)