(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid

• 产品号: B415725
• CAS号: 193146-26-8
• 分子式: C39H71NO6SSi2
• 分子量: 738.22014

产品别名

• 标题: (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid
• IUPAC标准名: (3S,7R,8S,9S,12Z,15S,16E)-3,8-bis[(tert-butyldimethylsilyl)oxy]-15-hydroxy-4,4,7,9,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-6-oxoheptadeca-12,16-dienoic acid
• IUPAC传统名: (3S,7R,8S,9S,12Z,15S,16E)-3,8-bis[(tert-butyldimethylsilyl)oxy]-15-hydroxy-4,4,7,9,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-6-oxoheptadeca-12,16-dienoic acid
• 别名: [3S-(3R*,6S*,7R*,8R*,12Z,15R*,16E)]-3,7-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-12,16-heptadecadienoic Acid

产品登记号

• CAS号: 193146-26-8

产品性质

• 外观: Oil
• 溶解度: Chloroform
• 溶解度: Dichloromethane
• 溶解度: Ethanol
• 溶解度: Ethyl Acetate
• 溶解度: Methanol
• 溶解度: Toluene

产品详细信息

详细说明 (English)

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical

参考文献

• Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999)
• Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)