Atorvastatin-d5 Sodium Salt

• 产品号: A791752
• 分子式: C33H34FN2NaO5
• 分子量: 580.6216332
• 保 存: Hygroscopic, -20°C Freezer, Under inert atmosphere

产品别名

• 标题: Atorvastatin-d5 Sodium Salt
• IUPAC标准名: sodium (3R,5R)-7-[2-(4-fluorophenyl)-3-(^2H₅)phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
• IUPAC传统名: sodium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-(^2H₅)phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoate
• 别名: Lipitor-d5 Sodium; (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-(phenyl-d5)-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Sodium

产品性质

• 外观: Light Tan Solid
• 熔点: >205°C (dec.)
• 溶解度: Methanol
• 保存条件: Hygroscopic, -20°C Freezer, Under inert atmosphere

产品详细信息

详细说明 (English)

A deuterated selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

参考文献

• Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993)
• Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1993)
• Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (1993)