AS-703026

• 产品号: A780100
• CAS号: 1236699-92-5
• 分子式: C15H15FIN3O3
• 分子量: 431.2007732

产品别名

• 标题: AS-703026
• IUPAC标准名: N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide
• IUPAC传统名: N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide
• 别名: N-[(2S)-2,3-Dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide

产品登记号

• CAS号: 1236699-92-5

产品详细信息

详细说明 (English)

AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor, in human multiple myeloma (MM). AS703026 induces pleiotropic anti-myeloma activity in vitro and in vivo. MEK inhibitors are useful in the treatment of hyperproliferative diseases, such

参考文献

• Smith, M., et al.: Leukemia, 17, 274 (1995)
• Adjei, A., et al.: J. Clin. Oncol., 26, 2139 (1995)
• Billadeau, D., et al.: Cancer Res., 55, 3640 (1995)
• Kolch, W., et al.: Biochem. J., 351, 289 (1995)