6-ANILINO-5,8-QUINOLINEDIONE

• 产品号: A664500
• CAS号: 91300-60-6
• 分子式: C15H10N2O2
• 分子量: 250.2521

产品别名

• 标题: 6-ANILINO-5,8-QUINOLINEDIONE
• IUPAC标准名: 6-(phenylamino)-5,8-dihydroquinoline-5,8-dione
• IUPAC传统名: 6-(phenylamino)quinoline-5,8-dione
• 别名: 6-Anilinoquinoline-5,8-quinone; 6-(Phenylamino)-5,8-quinolinedione; 5,8-Dihydro-5,8-dioxo-6-(phenylamino)quinoline; LY 83583

产品登记号

• CAS号: 91300-60-6

产品性质

• 外观: Red-Brown Solid
• 熔点: 184-185°C
• 溶解度: Dichloromethane

产品详细信息

详细说明 (English)

Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2μM) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release.

参考文献

• Macleod, K.M., et al.: Mol. Pharmacol., 32, 59 (1987)
• Mulsch, A. J.: J. Pharmacol. Exp. Ther., 247, 283 (1987)
• Mulsch, A., et al.: Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 119 (1987)
• Light, D.B., et al.: Science, 243, 383 (1987)
• Beasley, D., et al