2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile Trifluoroacetate

• 产品号: A627960
• CAS号: 928201-45-0
• 分子式: C20H21F4N5O4
• 分子量: 471.4054528

产品别名

• 标题: 2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile Trifluoroacetate
• IUPAC标准名: 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)-4-fluorobenzonitrile; trifluoroacetic acid
• IUPAC传统名: 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl}methyl)-4-fluorobenzonitrile; trifluoroacetic acid

产品登记号

• CAS号: 928201-45-0

产品详细信息

详细说明 (English)

2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile trifluoroacetate is a potent, selective, and noncovalent inhibitor of dipeptidyl peptidase IV (DPP-4). This inhibitor provides sustained reduc

参考文献

• Augeri, D., et al.: J. Med. Chem., 48, 5025 (2005)
• Drucker, D., et al.: Lancet, 368, 1696 (2005)
• Cvetkovic, R., et al.: Drugs, 67, 935 (2005)