4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine

• 产品号: A602985
• CAS号: 956025-99-3
• 分子式: C16H18BrN5
• 分子量: 360.25162

产品别名

• 标题: 4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine
• IUPAC标准名: 3-[(3-bromophenyl)methyl]-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• IUPAC传统名: 3-[(3-bromophenyl)methyl]-1-tert-butylpyrazolo[3,4-d]pyrimidin-4-amine
• 别名: 3-[(3-Bromophenyl)methyl]-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 3-BrB-PP1

产品登记号

• CAS号: 956025-99-3

产品详细信息

详细说明 (English)

4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine is a small molecule Akt inhibitor. The kinase Akt is a key signaling node in regulating cellular growth and survival.

参考文献

• Eblen, S., et al.: J. Biol. Chem., 278, 14926 (2003)
• Lindsley, C., et al.: Bioorg. Med. Chem. Lett., 15, 761 (2003)
• Manning, B., et al.: Cell, 129, 1261 (2003)
• Heerding, D., et al.: J. Med. Chem., 51, 5663 (2003)