Aloisine A RP107

• 产品号: A575450
• CAS号: 496864-16-5
• 分子式: C16H17N3O
• 分子量: 267.32568
• 保 存: -20°C Freezer

产品别名

• 标题: Aloisine A RP107
• IUPAC标准名: 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol
• IUPAC传统名: 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol
• 别名: RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol

产品登记号

• CAS号: 496864-16-5

产品性质

• 外观: Yellow solid
• 熔点: 281-283°C
• 溶解度: DMSO
• 溶解度: Methanol
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,

参考文献

• Mattey, Y., et al.: J. Med. Chem., 46, 222 (2003)
• Noel, S., et al.: J. Pharmacol. Exp. Ther., 319, 349 (2003)
• Mitsuhashi, M., et al.: Pharm. Res., 25, 1116 (2003)