17-(Allylamino-d5) Geldanamycin

• 产品号: A549652
• 分子式: C31H43N3O8
• 分子量: 585.68842
• 保 存: -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: 17-(Allylamino-d5) Geldanamycin
• IUPAC标准名: (4E,6Z,8R,9S,10E,12S,13R,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-[(prop-2-en-1-yl)amino]-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• IUPAC传统名: (4E,6Z,8R,9S,10E,12S,13R,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• 别名: NSC 330507-d5; 17-(Allylamino-d5)-17-demethoxygeldanamycin; CP 127374-d5; Tanespimycin-d5; 17-Demethoxy-17-(allylamino-d5)geldanamycin; 17-Demethoxy-17-(2-propenylamino-d5)geldanamycin; 17-(Allylamino-d5)-17-desmethylgeldanamycin; 17AAG-d5; KOS 953-d5

产品性质

• 外观: Dark Purple Solid
• 熔点: 161-163°C
• 溶解度: DMSO
• 溶解度: Methanol
• 保存条件: -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.

参考文献

• Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995)
• Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (1995)
• Basso, A.D., et al.: Oncogene, 21, 1159 (1995)