Agomelatine-d4

• 产品号: A430002
• 分子式: C15H17NO2
• 分子量: 243.30098

产品别名

• 标题: Agomelatine-d4
• IUPAC标准名: N-[2-(7-methoxynaphthalen-1-yl)(^2H₄)ethyl]acetamide
• IUPAC传统名: N-[2-(7-methoxynaphthalen-1-yl)(^2H₄)ethyl]acetamide
• 别名: N-[2-(7-Methoxy-1-naphthalenyl)ethyl-d4]acetamide; Valdoxan-d4; N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide-d4; S 20098-d4

产品详细信息

详细说明 (English)

Labelled Agomelatine, a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned,

参考文献

• Yous, S., et al.: J. Med. Chem., 35, 1484 (1992)
• Zhdanova, I., et al.: J. Clin. Endocrinol. Metab., 86, 4727 (1992)
• Cajochen, C., et al.: J. Pineal Res., 35, 149 (1992)