ABT 263

• 产品号: A112500
• CAS号: 923564-51-6
• 分子式: C47H55ClF3N5O6S3
• 分子量: 974.6127096
• 保 存: -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: ABT 263
• IUPAC标准名: 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide
• IUPAC传统名: 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide
• 别名: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide

产品登记号

• CAS号: 923564-51-6

产品性质

• 外观: Pale Yellow Solid
• 熔点: 114-116°C
• 溶解度: Chloroform
• 溶解度: DMSO
• 溶解度: Methanol
• 保存条件: -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.

参考文献

• Adams, J., et al.: Science, 281, 1322 (1998)
• Degterev, A., et al.: Nat. Cell. Biol., 3, 173 (1998)
• Kitada, S., et al.: J. Med. Chem., 46, 4259 (1998)
• Danial, N., et al.: Clin. Cancer Res., 13, 7254 (1998)