Biochem/physiol Actions Inhibits induction of macrophage nitric oxide synthase. Other Notes Reagent used for the extraction of trace metals into organic solvents for atomic absorption spectroscopy1,2; Precipitation of trace metals for x-ray fluorescence spectroscopy 3 Application Spin trap used in conjunction with Fe2+ to detect NO in brain, kidney, liver, and other tissues. Simultaneous direct measurement of NO* and pO2 has been reported. A copper chelator, it has been used to quantitate copper in biological materials by ESR and is an inhibitor of superoxide dismutase, ascorbate oxidase, and other enzymes. |